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Research use only. Not for human or veterinary use. €200 minimum order
For research use only. Products sold by Peptide Shop are intended for in-vitro laboratory research only. Not for human or veterinary diagnostic, therapeutic, cosmetic or consumption purposes.
Autocamtide-2-related Inhibitory Peptide (AIP) — 1 mg, ≥98 % HPLC product vial
Cell Signaling

Autocamtide-2-related Inhibitory Peptide (AIP) — 1 mg, ≥98 % HPLC

>- AIP — the most selective Ca²⁺/calmodulin-dependent protein kinase II inhibitor peptide. ≥98% HPLC. RUO.

≥ 98% COA supported RUO
CAS
167114-91-2
Molecular weight
1771.0 g/mol
Storage
-20°C lyophilised, desiccated, protected from light (research only)
Package sizes
1 × 1 mg vial

Description

AIP (Autocamtide-2-related Inhibitory Peptide) is a highly selective Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) inhibitor derived from the autoregulatory domain of the kinase. It is the reference CaMKII inhibitor in cell-signalling research.

Peptide Shop supplies AIP (CaMKII inhibitor) (1 × 1 mg vial) as a sealed research material with lot-level documentation. This product is supplied for in-vitro laboratory research only and is not intended for human use, veterinary use, therapy, diagnosis, cosmetic application or consumption.

Research applications

  • In-vitro CaMKII inhibition (IC50 ≈ 40 nM)
  • Synaptic plasticity and LTP/LTD research
  • Cardiac CaMKII research models
  • Reference inhibitor for CaMKII-selective small-molecule screens

Sequence and analytical data

Identity confirmed by ESI-MS. Highly water-soluble; cationic — use low-binding tubes.

Storage and handling

Store lyophilised at -20 °C. Aqueous stocks at -80 °C; avoid freeze-thaw.

Documentation

A lot-specific Certificate of Analysis is available in EN, DE, FR and ES from the product detail page after dispatch. The CoA reports HPLC purity, identity confirmation, appearance, and storage and handling guidance for the dispatched lot.

Sequence & data

Product IDpeptide-aip-camkii-inhibitor
CAS167114-91-2
Molecular weight1771.0 g/mol
Purity≥ 98%
SequenceKKALRRQEAVDAL

Storage & handling

-20°C lyophilised, desiccated, protected from light (research only)

Keep lyophilised material sealed and protected from moisture. Reconstituted materials should be handled according to validated laboratory protocols and disposed of as research waste.

Certificate of analysis

Batch-specific COA documentation is supplied according to the COA policy and may include HPLC purity, identity and lot information where available.

Other languages

FAQs

How selective is AIP for CaMKII?

AIP shows >100-fold selectivity for CaMKII over PKA, PKC and CaMKIV in standard kinase panel assays.

Is this material cell-permeable?

No — for intact-cell research use the myristoylated AIP variant (available on request).

Recommended assay concentration?

In-vitro: 0.1–10 µM. Permeabilised cells: 1–10 µM.