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Research use only. Not for human or veterinary use. €200 minimum order
For research use only. Products sold by Peptide Shop are intended for in-vitro laboratory research only. Not for human or veterinary diagnostic, therapeutic, cosmetic or consumption purposes.
Retatrutide 5 mg — research grade product vial
Diabetes & Metabolism

Retatrutide 5 mg — research grade

Retatrutide triple agonist research peptide for GLP-1, GIP and glucagon pathway models. COA supplied. RUO.

≥ 99% COA supported RUO
CAS
2381089-83-2
Molecular weight
4156.48 g/mol
Storage
-20°C recommended (research-only)
Package sizes
1 × 5 mg vial

Description

Retatrutide 10 mg research overview

Retatrutide triple agonist research peptide for GLP-1, GIP and glucagon pathway models. COA supplied. RUO.

Retatrutide is a triple GLP-1, GIP and glucagon receptor agonist reference peptide for multi-incretin metabolic research.

Peptide Shop supplies Retatrutide 10 mg as a sealed research material with lot-level documentation where available. This product is supplied for in-vitro laboratory research only and is not intended for human or veterinary diagnostic, therapeutic, cosmetic or consumption purposes.

Research use

  • Triple-receptor agonism and metabolic signalling
  • Energy-expenditure and glucose-regulation models
  • Comparative studies against single and dual incretin agonists

Position within diabetes and weight-loss research clusters for internal linking.

Sequence and analytical data

FieldDetail
Product IDpeptide-retatrutide
Package size1 × 5 mg vial
CAS number2381089-83-2
Molecular weight4156.48 g/mol
Purity≥ 99%
Storage-20°C recommended (research-only)

Batch-specific documentation may include HPLC purity, identity confirmation and lot information. Refer to the supplied COA or the COA policy for current documentation scope.

Reconstitution and handling

Allow lyophilised material to equilibrate before opening to reduce condensation risk. Add validated solvent slowly down the vial wall, avoid vigorous shaking, and record the final concentration in the laboratory notebook or LIMS.

Use aseptic technique, calibrated pipettes or syringes, and validated diluent choices for the assay system. Reconstituted materials should be aliquoted where appropriate to reduce repeated freeze-thaw exposure.

Storage

Store unopened material according to the stated condition: -20°C recommended (research-only). Keep vials sealed, dry and protected from light. Reconstituted solutions should be stored under validated laboratory conditions and discarded according to internal SOPs and applicable research-waste rules.

Research-use statement

Retatrutide 10 mg is sold by Peptide Shop for research use only. It is not a medicine, food, cosmetic, supplement or diagnostic product. Buyers are responsible for ensuring lawful purchase, storage, handling and disposal under their institutional and local requirements.

References

  1. Jastreboff AM et al. “Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial.” N Engl J Med. 2023;389(6):514–526. PMID 37506189
  2. Rosenstock J et al. “Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA.” Lancet. 2023;402(10401):529–544. PMID 37506190
  3. Coskun T et al. “LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept.” Cell Metab. 2022;34(9):1234–1247.e9. PMID 36070795

Sequence & data

Product IDpeptide-retatrutide
CAS2381089-83-2
Molecular weight4156.48 g/mol
Purity≥ 99%

Storage & handling

-20°C recommended (research-only)

Keep lyophilised material sealed and protected from moisture. Reconstituted materials should be handled according to validated laboratory protocols and disposed of as research waste.

Certificate of analysis

Batch-specific COA documentation is supplied according to the COA policy and may include HPLC purity, identity and lot information where available.

Other languages

FAQs

What makes Retatrutide unique compared to other incretin peptides?

Retatrutide is a triple agonist that activates GLP-1, GIP, and glucagon receptors simultaneously. This distinguishes it from dual agonists like tirzepatide (GIP/GLP-1) and mono-agonists like semaglutide (GLP-1 only), providing researchers a novel tool for studying multi-receptor metabolic effects.

What is Retatrutide used for in research?

Retatrutide is used in metabolic research to study triple receptor activation effects on glucose homeostasis, weight management, energy expenditure, hepatic lipid metabolism, and appetite regulation. The glucagon component adds unique thermogenic and lipolytic research applications.

How should Retatrutide be stored?

Store lyophilised Retatrutide at -20°C for optimal stability. Once reconstituted, keep at 2-8°C and use within 3-4 weeks. Avoid repeated freeze-thaw cycles and protect from light exposure.

What purity is your Retatrutide?

Our Retatrutide is ≥99% pure as verified by HPLC analysis. Each batch includes a Certificate of Analysis with purity data, mass spectrometry identity confirmation, and peptide content analysis.

How does the glucagon component contribute to research?

The glucagon receptor agonism provides unique research opportunities in studying hepatic glucose production, thermogenesis, lipolysis, and energy expenditure mechanisms not achievable with GLP-1/GIP dual agonists alone.

What is the half-life of Retatrutide?

Retatrutide has an extended half-life of approximately 6 days due to fatty acid modifications that enable albumin binding. This allows researchers to study sustained triple receptor activation effects.

How do I reconstitute Retatrutide?

Reconstitute in sterile bacteriostatic water or slightly alkaline buffer (pH 7.4-8.0). Add solvent slowly along the vial wall and gently swirl to dissolve. Avoid shaking vigorously.

What sizes are available?

Retatrutide is available in 5mg and 10mg vials. Larger quantities are available for institutional research projects - contact us for bulk pricing.

What is retatrutide?

Retatrutide (LY3437943) is a triple GLP-1/GIP/glucagon receptor agonist peptide. It targets three hormone receptors simultaneously, providing a unique pharmacological profile for obesity and metabolic pathway research. CAS number 2381089-83-2.

How does retatrutide differ from tirzepatide and semaglutide?

Retatrutide adds glucagon receptor agonism to the GLP-1/GIP dual agonism of tirzepatide. This triple-agonist profile makes it a uniquely complex research tool for studying combined incretin and glucagon signalling.

What is the molecular weight of retatrutide?

Retatrutide has an approximate molecular weight of 4723 g/mol. It is a 36-amino acid synthetic peptide with CAS number 2381089-83-2.

What documentation is included with retatrutide?

Each order includes a lot-specific COA with HPLC purity and identity data. Given synthesis complexity, both HPLC and mass spectrometry data are included where available.